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CRISPR/Cas and Hepatitis B Therapy: Technological Advances and Practical Barriers

19 Nov 2021

Abstract excerpt

After almost a decade of using CRISPR/Cas9 systems to edit target genes, CRISPR/Cas9 and related technologies are rapidly moving to clinical trials. Hepatitis B virus (HBV), which causes severe liver disease, cannot be cleared by modern antivirals, but represents an ideal target for CRISPR/Cas9 systems. Early studies demonstrated very high antiviral potency of CRISPR/Cas9 and supported its use for developing a...

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PMID: 34797701
DOI: 10.1089/nat.2021.0075

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