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CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X

3 Sept 2015

Abstract excerpt

Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in host cells as episomal covalently closed circular DNA (cccDNA) and, to a lesser extent, as chromosomally integrated sequences. However, novel designer enzymes, such as the CRISPR/Cas9 RNA-guided nuclease system, provide technologies for...

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PMID: 26334116
DOI: 10.1038/srep13734

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