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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

2 Jun 2015

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may offer the ability to directly cleave viral DNA, thereby promoting viral clearance. Here, we show that the CRISPR/Cas9 system can specifically target and cleave conserved regions in the HBV genome, resulting in robust...

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PMID: 26035283
DOI: 10.1038/srep10833

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