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Article

Application of CRISPR/Cas9 Technology to HBV

2 Nov 2015

Abstract excerpt

More than 240 million people around the world are chronically infected with hepatitis B virus (HBV). Nucleos(t)ide analogs and interferon are the only two families of drugs to treat HBV currently. However, none of these anti-virals directly target the stable nuclear covalently closed circular DNA (cccDNA), which acts as a transcription template for viral mRNA and pre-genomic RNA synthesis and secures virus...

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PMID: 26540039
DOI: 10.3390/ijms161125950

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