Article
An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation.
International journal of biological sciences - 1 Jan 2016
Li Hao, Sheng Chunyu, Liu Hongbo, Liu Guangze, Du Xinying, Du Juan, Zhan Linsheng, Li Peng, Yang Chaojie, Qi Lihua, Wang Jian, Yang Xiaoxia, Jia Leili, Xie Jing, Wang Ligui, Hao Rongzhang, Xu Dongping, Tong Yigang, Zhou Yusen, Zhou Jianjun, Sun Yansong, Li Qiao, Qiu Shaofu, Song Hongbin
Abstract excerpt
Chronic hepatitis B infection remains incurable because HBV cccDNA can persist indefinitely in patients recovering from acute HBV infection. Given the incidence of HBV infection and the shortcomings of current therapeutic options, a novel antiviral strategy is urgently needed. To inactivate HBV replication and destroy the HBV genome, we employed genome editing tool CRISPR/Cas9. Specifically, we found a...
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