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Article

Synthetic gRNA/Cas9 ribonucleoprotein targeting HBV DNA inhibits viral replication

1 Jul 2023

Abstract excerpt

The presence of hepatitis B virus (HBV) covalently closed circular (ccc) DNA (cccDNA), which serves as a template for viral replication and integration of HBV DNA into the host cell genome, sustains liver pathogenesis and constitutes an intractable barrier to the eradication of chronic HBV infection. The current antiviral therapy for HBV infection, using nucleos(t)ide analogues (NAs), can suppress HBV replication...

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PMID: 37455550
DOI: 10.1002/jmv.28952

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