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Recent Progress and Future Prospective in HBV Cure by CRISPR/Cas

21 Dec 2021

Abstract excerpt

Hepatitis B virus (HBV) infection remains an important issue of global public health. Although current antiviral therapy has dramatically reduced the mortality and morbidity of chronic hepatitis B (CHB), it fails to cure it. Rebound viremia often occurs after stopping antiviral therapy. Persistent HBV covalently closed circular DNA (cccDNA) and integrated DNA under antiviral therapy form the major barrier to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35062208
DOI: 10.3390/v14010004

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