Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2016

Ely Abdullah, Moyo Buhle, Arbuthnot Patrick

Abstract excerpt

Chronic infection with hepatitis B virus (HBV) occurs in approximately 6% of the world's population. Carriers of the virus are at risk for life-threatening complications, and developing curative treatment remains a priority. The main shortcoming of licensed therapies is that they do not affect viral covalently closed circular DNA (cccDNA), a stable intermediate of replication. Harnessing gene editing to mutate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Gene Editing

Share to Genetic Therapy

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 26916283
DOI: 10.1038/mt.2016.43
PMCID: PMC4886943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus.PMID 26916283Read ↗

Gene-Editing and RNA Interference in Treating Hepatitis B: A ReviewSemantic proximity Read ↗

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?Semantic proximity Read ↗

CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized miceSemantic proximity Read ↗

CRISPR/Cas9 for hepatitis B virus infection treatmentSemantic proximity Read ↗

The progress of molecules and strategies for the treatment of HBV infectionSemantic proximity Read ↗

CRISPR/Cas and Hepatitis B Therapy: Technological Advances and Practical BarriersSemantic proximity Read ↗

Advances with RNAi-Based Therapy for Hepatitis B Virus InfectionSemantic proximity Read ↗

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virusSemantic proximity Read ↗

Recent Progress and Future Prospective in HBV Cure by CRISPR/CasSemantic proximity Read ↗

Application of CRISPR/Cas9 Technology to HBVSemantic proximity Read ↗

Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.Semantic proximity Read ↗

CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal VariantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.