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Article

Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016

Williams Helen, Mill Carina A E, Monk Bethan A, Hulin-Curtis Sarah, Johnson Jason L, George Sarah J

Abstract excerpt

OBJECTIVE: Increased vascular smooth muscle cell (VSMC) migration leads to intimal thickening which acts as a soil for atherosclersosis, as well as causing coronary artery restenosis after stenting and vein graft failure. Investigating factors involved in VSMC migration may enable us to reduce intimal thickening and improve patient outcomes. In this study, we determined whether Wnt proteins regulate VSMC...

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Source

Identifiers

PMID: 27199447
DOI: 10.1161/ATVBAHA.116.307626

Genes

CCN4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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