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Article

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2011

Ono Mitsuaki, Inkson Colette A, Kilts Tina M, Young Marian F

Abstract excerpt

Wnt-induced secreted protein 1 (WISP-1/CCN4) is a member of the CCN family that is highly expressed in skeletal tissue and in osteoprogenitor cells induced to differentiate in vitro. To determine the function of WISP-1 during osteogeneis, osteogenic bone marrow stromal cells (BMSCs) were transduced with WISP-1 adenovirus (adWISP-1) in the presence or absence of bone morphogenetic protein 2 (BMP-2) adenovirus...

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Source

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Identifiers

PMID: 20684029
DOI: 10.1002/jbmr.205
PMCID: PMC3179320

Genes

CCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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