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Article

miR-22 Is a Novel Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation and Neointima Formation.

Circulation - 24 Apr 2018

Yang Feng, Chen Qishan, He Shiping, Yang Mei, Maguire Eithne Margaret, An Weiwei, Afzal Tayyab Adeel, Luong Le Anh, Zhang Li, Xiao Qingzhong

Abstract excerpt

BACKGROUND: MicroRNA-22 (miR-22) has recently been reported to play a regulatory role during vascular smooth muscle cell (VSMC) differentiation from stem cells, but little is known about its target genes and related pathways in mature VSMC phenotypic modulation or its clinical implication in neointima formation following vascular injury. METHODS: We applied a wire-injury mouse model, and local delivery of...

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Identifiers

PMID: 29246895
DOI: 10.1161/CIRCULATIONAHA.117.027799
PMCID: PMC5916488

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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