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Article

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation.

Journal of cellular physiology - 1 Dec 2011

Reddy Venkatapuram Seenu, Valente Anthony J, Delafontaine Patrice, Chandrasekar Bysani

Abstract excerpt

We demonstrate for the first time that the pro-inflammatory cytokine interleukin (IL)-18 stimulates rapid and significant proliferation of SMC derived from human saphenous vein (VSMC), but not coronary artery. IL-18 also stimulates VSMC growth. Further investigations revealed that IL-18-induced VSMC proliferation was Wnt inducible secreted protein-1 (WISP1) dependent. In addition to inducing its own expression...

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Source

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Identifiers

PMID: 21321938
DOI: 10.1002/jcp.22676
PMCID: PMC3111842

Genes

WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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