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Article

The α11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2016

Civitarese Robert A, Talior-Volodarsky Ilana, Desjardins Jean-Francois, Kabir Golam, Switzer Jennifer, Mitchell Melissa, Kapus Andras, McCulloch Christopher A, Gullberg Donald, Connelly Kim A

Abstract excerpt

Excessive cardiac interstitial fibrosis impairs normal cardiac function. We have shown that the α11β1 (α11) integrin mediates fibrotic responses to glycated collagen in rat myocardium by a pathway involving transforming growth factor-β. Little is known of the role of the α11 integrin in the developing mammalian heart. Therefore, we examined the impact of deletion of the α11 integrin in wild-type mice and in mice...

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PMID: 27199132
DOI: 10.1152/ajpheart.00918.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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