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Article

αv integrins: key regulators of tissue fibrosis

2 May 2016

Abstract excerpt

Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic therapies is urgently required. During fibrogenesis, complex interplay occurs between cellular and extracellular matrix components of the wound healing response. Integrins, a family of transmembrane cell adhesion molecules, play a...

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PMID: 27139180
DOI: 10.1007/s00441-016-2407-9

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