Article

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice

2022-07-01

Abstract excerpt

Diabetes-induced cardiomyopathy is characterized by myocardial fibrosis as a main pathology. In-depth study of cardiac heterogeneity and cell-to-cell interactions will help to reveal the pathogenesis of diabetic myocardial fibrosis and provide potential targets for the treatment of this disease. Here, we insighted into the intercellular communication drivers underlying myocardial fibrosis in mouse heart with high-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a071bd5-7a13-5534-91e4-0ea0c83d35ce
DOI: 10.1101/2022.06.29.498129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic MiceDOI 10.1101/2022.06.29.498129Read

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathySemantic proximity Read

Characterising Shared and Specific Cell–Cell Communication in Cardiomyopathy Subtypes From Single‐Cell Transcriptomics DataSemantic proximity Read

Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cellsSemantic proximity Read

Multi-organ single-cell RNA-sequencing reveals early hyperglycaemia responses that converge on fibroblast dysregulationSemantic proximity Read

Single cell study of cellular diversity and mutual communication in chronic heart failure and drug repositioningSemantic proximity Read

Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk TranscriptomesSemantic proximity Read

Multi‐organ single‐cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulationSemantic proximity Read

Identification of macrophage driver genes in fibrosis caused by different heart diseases based on omics integrationSemantic proximity Read

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart FailureSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fractionSemantic proximity Read