Article
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.
Nature communications - 24 Oct 2017
Murray I R, Gonzalez Z N, Baily J, Dobie R, Wallace R J, Mackinnon A C, Smith J R, Greenhalgh S N, Thompson A I, Conroy K P, Griggs D W, Ruminski P G, Gray G A, Singh M, Campbell M A, Kendall T J, Dai J, Li Y, Iredale J P, Simpson H, Huard J, Péault B, Henderson N C
Abstract excerpt
Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ+ cells contribute to skeletal muscle and cardiac fibrosis via a mechanism that depends on αv integrins. Mice in which αv integrin is depleted in PDGFRβ+ cells are protected from cardiotoxin and laceration-induced skeletal muscle...
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