Article
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases.
Experimental & molecular medicine - 17 Nov 2017
Bansal Ruchi, Nakagawa Shigeki, Yazdani Saleh, van Baarlen Joop, Venkatesh Anu, Koh Anna P, Song Won-Min, Goossens Nicolas, Watanabe Hideo, Beasley Mary B, Powell Charles A, Storm Gert, Kaminski Naftali, van Goor Harry, Friedman Scott L, Hoshida Yujin, Prakash Jai
Abstract excerpt
Tissue fibrosis, characterized by excessive accumulation of aberrant extracellular matrix (ECM) produced by myofibroblasts, is a growing cause of mortality worldwide. Understanding the factors that induce myofibroblastic differentiation is paramount to prevent or reverse the fibrogenic process. Integrin-mediated interaction between the ECM and cytoskeleton promotes myofibroblast differentiation. In the present...
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