Article
Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.
Life sciences - 28 Mar 2013
Fowlkes Vennece, Clark Jessica, Fix Charity, Law Brittany A, Morales Mary O, Qiao Xian, Ako-Asare Kayla, Goldsmith Jack G, Carver Wayne, Murray David B, Goldsmith Edie C
Abstract excerpt
AIMS: Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition remain unclear. The goal of this study was to evaluate whether cardiac fibroblast function is...
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