Article
Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH.
International journal of cancer - 1 Oct 2016
Win Aung Ko, Reece Jeanette C, Dowty James G, Buchanan Daniel D, Clendenning Mark, Rosty Christophe, Southey Melissa C, Young Joanne P, Cleary Sean P, Kim Hyeja, Cotterchio Michelle, Macrae Finlay A, Tucker Katherine M, Baron John A, Burnett Terrilea, Le Marchand Loïc, Casey Graham, Haile Robert W, Newcomb Polly A, Thibodeau Stephen N, Hopper John L, Gallinger Steven, Winship Ingrid M, Lindor Noralane M, Jenkins Mark A
Abstract excerpt
Germline mutations in the DNA base excision repair gene MUTYH are known to increase a carrier's risk of colorectal cancer. However, the risks of other (extracolonic) cancers for MUTYH mutation carriers are not well defined. We identified 266 probands (91% Caucasians) with a MUTYH mutation (41 biallelic and 225 monoallelic) from the Colon Cancer Family Registry. Mutation status, sex, age and histories of cancer...
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