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Article

MUTYH as an Emerging Predictive Biomarker in Ovarian Cancer

6 Jan 2021

Abstract excerpt

Approximately 18% of ovarian cancers have an underlying genetic predisposition and many of the genetic alterations have become intervention and therapy targets. Although mutations in MutY homolog (MUTYH) are best known for MUTYH associated polyposis and colorectal cancer, it plays a role in the development of ovarian cancer. In this review, we discuss the function of the MUTYH gene, mutation epidemiology, and its...

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PMID: 33419231
DOI: 10.3390/diagnostics11010084

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