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Article

Clinical implications of the colorectal cancer risk associated with MUTYH mutation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2009

Lubbe Steven J, Di Bernardo Maria Chiara, Chandler Ian P, Houlston Richard S

Abstract excerpt

PURPOSE: Biallelic mutations in the base excision DNA repair gene MUTYH predispose to colorectal cancer (CRC). Evidence that monoallelic mutations also confer an elevated CRC risk is controversial. Precise quantification of the CRC risk and the phenotype associated with MUTYH mutations is relevan...

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Source

Identifiers

PMID: 19620482
DOI: 10.1200/JCO.2008.21.6853

Genes

MUTYH
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620482-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Clinical implications of the colorectal cancer risk associated with MUTYH mutation.PMID 19620482Read ↗

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Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis.Semantic proximity Read ↗

Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer.Semantic proximity Read ↗

Analysis of MUTYH genotypes and colorectal phenotypes in patients With MUTYH-associated polyposis.Semantic proximity Read ↗

Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review.Semantic proximity Read ↗

MUTYH-associated tumor syndrome: The other face of MAP.Semantic proximity Read ↗

A comprehensive characterization of the spectrum of MUTYH germline pathogenic variants in Latin America.Semantic proximity Read ↗

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