Article
Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH.
Gastroenterology - 1 Aug 2009
Jones Natalie, Vogt Stefanie, Nielsen Maartje, Christian Daria, Wark Petra A, Eccles Diana, Edwards Emma, Evans D Gareth, Maher Eamonn R, Vasen Hans F, Hes Frederik J, Aretz Stefan, Sampson Julian R
Abstract excerpt
BACKGROUND & AIMS: MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal and other cancers in heterozygous carriers of a single MUTYH mutation are uncertain. We performed a retrospective study of cancer incidence and causes of death among obligate MUTYH heterozygote...
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