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Article

Germline susceptibility to colorectal cancer due to base-excision repair gene defects.

American journal of human genetics - 1 Jul 2005

Farrington Susan M, Tenesa Albert, Barnetson Rebecca, Wiltshire Alice, Prendergast James, Porteous Mary, Campbell Harry, Dunlop Malcolm G

Abstract excerpt

DNA repair is a key process in the maintenance of genome integrity. Here, we present a large, systematically collected population-based association study (2,239 cases; 1,845 controls) that explores the contribution to colorectal cancer incidence of inherited defects in base-excision repair (BER) genes. We show that biallelic MUTYH defects impart a 93-fold (95% CI 42-213) excess risk of colorectal cancer, which...

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Source

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Identifiers

PMID: 15931596
DOI: 10.1086/431213
PMCID: PMC1226182

Genes

MUTYH
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline susceptibility to colorectal cancer due to base-excision repair gene defects.PMID 15931596Read ↗

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