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Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2022

Downie Jonathan M, Riaz Moeen, Xie Jing, Lee Minyi, Chan Andrew T, Gibbs Peter, Orchard Suzanne G, Mahady Suzanne E, Sebra Robert P, Murray Anne M, Macrae Finlay, Schadt Eric, Woods Robyn L, McNeil John J, Lacaze Paul, Gala Manish

Abstract excerpt

MUTYH carriers have an increased colorectal cancer risk in case-control studies, with loss of heterozygosity (LOH) as the presumed mechanism. We evaluated cancer risk among carriers in a prospective, population-based cohort of older adults. In addition, we assessed if cancers from carriers demonstrated mutational signatures (G:C>T:A transversions) associated with early LOH. We calculated incident risk of cancer...

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PMID: 35609203
DOI: 10.1158/1940-6207.CAPR-22-0080
PMCID: PMC9356994

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