Article
Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene.
Familial cancer - 1 Dec 2015
Win Aung Ko, Reece Jeanette C, Buchanan Daniel D, Clendenning Mark, Young Joanne P, Cleary Sean P, Kim Hyeja, Cotterchio Michelle, Dowty James G, MacInnis Robert J, Tucker Katherine M, Winship Ingrid M, Macrae Finlay A, Burnett Terrilea, Le Marchand Loïc, Casey Graham, Haile Robert W, Newcomb Polly A, Thibodeau Stephen N, Lindor Noralane M, Hopper John L, Gallinger Steven, Jenkins Mark A
Abstract excerpt
The base excision repair protein, MUTYH, functionally interacts with the DNA mismatch repair (MMR) system. As genetic testing moves from testing one gene at a time, to gene panel and whole exome next generation sequencing approaches, understandin g the risk associated with co-existence of germline mutations in these genes will be important for clinical interpretation and management. From the Colon Cancer Family...
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