Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis.

Familial cancer - 1 Mar 2011

Win Aung Ko, Hopper John L, Jenkins Mark A

Abstract excerpt

Whether people who inherit a mutation in MUTYH from only one parent (monoallelic mutation) are at increased risk of colorectal cancer (CRC) remains controversial. Most previous studies and meta-analyses have not found statistically significant associations but, given carriers are relatively rare, may be underpowered to detect small increased risks. We have conducted a systematic review and meta-regression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Case-Control Studies
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to MUTYH gene

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21061173
DOI: 10.1007/s10689-010-9399-5
PMCID: PMC3228836

Genes

MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis.PMID 21061173Read ↗

Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer.Semantic proximity Read ↗

Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer.Semantic proximity Read ↗

Association of MUTYH and colorectal cancer.Semantic proximity Read ↗

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants.Semantic proximity Read ↗

Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH.Semantic proximity Read ↗

Clinical implications of the colorectal cancer risk associated with MUTYH mutation.Semantic proximity Read ↗

Monoallelic MUTYH pathogenic variants ascertained via multi-gene hereditary cancer panels are not associated with colorectal, endometrial, or breast cancer.Semantic proximity Read ↗

Risk of colorectal adenomas and cancer in monoallelic carriers of MUTYH pathogenic variants: a single-centre experience.Semantic proximity Read ↗

Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts.Semantic proximity Read ↗

Heterozygous deleterious MUTYH variants as a driver for tumorigenesisSemantic proximity Read ↗

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH.Semantic proximity Read ↗

Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.