Article
MUTYH-associated tumor syndrome: The other face of MAP.
Oncogene - 1 Apr 2022
Magrin Luigi, Fanale Daniele, Brando Chiara, Corsini Lidia Rita, Randazzo Ugo, Di Piazza Marianna, Gurrera Vittorio, Pedone Erika, Bazan Russo Tancredi Didier, Vieni Salvatore, Pantuso Gianni, Russo Antonio, Bazan Viviana
Abstract excerpt
MUTYH gene is involved in the base excision repair (BER) mechanism and its pathogenic alterations are associated with colorectal polyposis and cancer. MUTYH-associated polyposis (MAP) is a condition which is inherited in an autosomal recessive manner. MAP patients, beyond colorectal cancer (CRC), may develop other types of tumors, including duodenal, breast, ovarian, pancreatic, bladder and skin cancers. Carriers...
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