Article
Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer.
Gastroenterology - 1 May 2014
Win Aung Ko, Dowty James G, Cleary Sean P, Kim Hyeja, Buchanan Daniel D, Young Joanne P, Clendenning Mark, Rosty Christophe, MacInnis Robert J, Giles Graham G, Boussioutas Alex, Macrae Finlay A, Parry Susan, Goldblatt Jack, Baron John A, Burnett Terrilea, Le Marchand Loïc, Newcomb Polly A, Haile Robert W, Hopper John L, Cotterchio Michelle, Gallinger Steven, Lindor Noralane M, Tucker Katherine M, Winship Ingrid M, Jenkins Mark A
Abstract excerpt
We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%-11.3%) and 5.6% for female carriers of monoallelic mutations (95% CI, 3.6%-8.8%), irrespective of family history. For monoallelic MUTYH...
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