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Article

Clinicopathogenomic analysis of mismatch repair proficient colorectal adenocarcinoma uncovers novel prognostic subgroups with differing patterns of genetic evolution.

International journal of cancer - 1 Oct 2016

Braxton David R, Zhang Ray, Morrissette Jennifer D, Loaiza-Bonilla Arturo, Furth Emma E

Abstract excerpt

Cancer somatic genetic evolution is a direct contributor to heterogeneity at the clonal and molecular level in colorectal adenocarcinoma (COAD). We sought to determine the extent to which genetic evolution may be detected in COAD in routinely obtained single clinical specimens and establish clinical significance with regard to clinicopathologic and outcome data. One hundred and twenty three cases of routinely...

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Source

Identifiers

PMID: 27194209
DOI: 10.1002/ijc.30196

Genes

ERBB2
APC
FLT3
GNAS
KRAS
PTEN
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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