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Microsatellite Instability and Mismatch Repair Subclonality in Human Cancers: Biologic Basis, Diagnostic Pitfalls, and Therapeutic Implications With a Focus on Colorectal Cancer

2026-08-03

Abstract excerpt

<h4>Background: </h4> Microsatellite instability-high (MSI-H) and deficient mismatch repair (dMMR) define a molecular subtype of colorectal cancer (CRC) and predict benefit from immune checkpoint inhibition. Clinically, MSI/MMR assessment may yield discordant results across assays, anatomic sites, or time points. A challenging scenario occurs when tissue analysis identifies microsatellite-stable (MSS) or mismatch...

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Literature Corpus work: b99a54f1-a0a9-593d-b339-544b1fe71641
DOI: 10.20944/preprints202608.0049.v1

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