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Comprehensive assessment of genomic heterogeneity, coalterations, and outcomes of patients with colorectal cancer: An AACR GENIE project analysis.

Surgery - 1 Sept 2025

Stecko Hunter, Tsilimigras Diamantis I, Iyer Sidharth, Daw Jad, Zhu Hua, Huang Emily, Kalady Matthew, Pawlik Timothy M

Abstract excerpt

INTRODUCTION: Colorectal cancer remains a leading cause of cancer mortality in the United States and can be characterized by racial and sex-based disparities. The objective of the current study was to characterize the genomic heterogeneity of colorectal cancer among diverse demographic groups, assess coalteration patterns and their impact on long-term outcomes among patients with colorectal cancer. METHODS: Data...

Read the complete abstract on PubMed

Topics

Humans
Male
Colorectal Neoplasms
Female
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Registries

United States

Genetic Heterogeneity

Mutation

Aged, 80 and over

Source

Identifiers

PMID: 40517576
DOI: 10.1016/j.surg.2025.109475

Genes

KRAS
TP53
ARID1A
ATM
BRAF
CREBBP
FAT1
KMT2B
KMT2D

Provenance

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