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Article

Intra-tumor genetic heterogeneity in rectal cancer.

Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2016

Hardiman Karin M, Ulintz Peter J, Kuick Rork D, Hovelson Daniel H, Gates Christopher M, Bhasi Ashwini, Rodrigues Grant Ana, Liu Jianhua, Cani Andi K, Greenson Joel K, Tomlins Scott A, Fearon Eric R

Abstract excerpt

Colorectal cancer arises in part from the cumulative effects of multiple gene lesions. Recent studies in selected cancer types have revealed significant intra-tumor genetic heterogeneity and highlighted its potential role in disease progression and resistance to therapy. We hypothesized the existence of significant intra-tumor genetic heterogeneity in rectal cancers involving variations in localized somatic...

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Identifiers

PMID: 26568296
DOI: 10.1038/labinvest.2015.131
PMCID: PMC4695247

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