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Article

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer.

Nature communications - 16 Jan 2020

von Loga Katharina, Woolston Andrew, Punta Marco, Barber Louise J, Griffiths Beatrice, Semiannikova Maria, Spain Georgia, Challoner Benjamin, Fenwick Kerry, Simon Ronald, Marx Andreas, Sauter Guido, Lise Stefano, Matthews Nik, Gerlinger Marco

Abstract excerpt

Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability but their evolution has not been investigated. Here we apply multi-region exome sequencing (MSeq) to four treatment-naive dMMR GOAs. This reveals extreme...

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Identifiers

PMID: 31949146
DOI: 10.1038/s41467-019-13915-7
PMCID: PMC6965135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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