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Article

Mutational Patterns in Colorectal Cancer: Do PDX Models Retain the Heterogeneity of the Original Tumor?

International journal of molecular sciences - 26 May 2025

El Hage Maria, Su Zhaoran, Linnebacher Michael

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for a deeper understanding of the genetic mechanisms driving its development and progression. Identifying genetic mutations that affect key molecular pathways is crucial for advancing CRC diagnosis, prognosis, and treatment. Patient-derived xenograft (PDX) models are essential tools in precision medicine...

Read the complete abstract on PubMed

Topics

Colorectal Neoplasms
Humans
Mutation
Animals
Genetic Heterogeneity
Proto-Oncogene Proteins B-raf

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Mice

Xenograft Model Antitumor Assays

Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 40507920
DOI: 10.3390/ijms26115111
PMCID: PMC12154438

Genes

APC
BRAF
TP53
ERBB2
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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