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Article

Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer

15 Nov 2023

Abstract excerpt

Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote intratumour heterogeneity (ITH) and cancer evolution. We applied multiregion sequencing and CD8 and programmed death ligand 1 (PD-L1) immunostaining to systematically investigate ITH and how...

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PMID: 37964706
DOI: 10.1002/path.6228

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