Article
Next-Generation Sequencing of Multivergent Morphologies in Colorectal Carcinomas Identifies Unique Targetable Alterations.
The American journal of surgical pathology - 1 Oct 2026
Larson Brent K, Makhoul Elias, Gangi Alexandra, Gong Jun, Guindi Maha, Hendifar Andrew, Hutchings Danielle, Kozak Michael, Lai Keith, Osipov Arsen, Vail Eric, Waters Kevin M
Abstract excerpt
Typically, colorectal carcinoma (CRC) is morphologically relatively homogeneous. Uncommon morphologic patterns may be enriched for rare molecular drivers. This study examined the clinicopathologic characteristics of CRC with multivergent morphology (defined as 2 discrete nonconventional morphologic cytoarchitectural patterns) and whether potentially targetable molecular alterations could be identified by...
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- Humans
- Colorectal Neoplasms
- High-Throughput Nucleotide Sequencing
- Aged
- Female