Article
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Ivansson Emma L, Megquier Kate, Kozyrev Sergey V, Murén Eva, Körberg Izabella Baranowska, Swofford Ross, Koltookian Michele, Tonomura Noriko, Zeng Rong, Kolicheski Ana L, Hansen Liz, Katz Martin L, Johnson Gayle C, Johnson Gary S, Coates Joan R, Lindblad-Toh Kerstin
Abstract excerpt
Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS). Most dogs that develop DM are homozygous for a common superoxide dismutase 1 gene (SOD1) mutation. However, not all dogs homozygous for this mutation develop disease. We performed a genome-wide association analysis in the Pembroke Welsh Corgi (PWC) breed...
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