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Article

An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.

PLoS genetics - 1 Oct 2014

Ekenstedt Kari J, Becker Doreen, Minor Katie M, Shelton G Diane, Patterson Edward E, Bley Tim, Oevermann Anna, Bilzer Thomas, Leeb Tosso, Drögemüller Cord, Mickelson James R

Abstract excerpt

An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT) disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed PN, characterized by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as inspiratory...

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Identifiers

PMID: 25275565
DOI: 10.1371/journal.pgen.1004635
PMCID: PMC4183422

Genes

ARHGEF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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