Article
Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds.
PloS one - 1 Jan 2014
Schrauwen Isabelle, Barber Renee M, Schatzberg Scott J, Siniard Ashley L, Corneveaux Jason J, Porter Brian F, Vernau Karen M, Keesler Rebekah I, Matiasek Kaspar, Flegel Thomas, Miller Andrew D, Southard Teresa, Mariani Christopher L, Johnson Gayle C, Huentelman Matthew J
Abstract excerpt
Necrotizing meningoencephalitis (NME) affects toy and small breed dogs causing progressive, often fatal, inflammation and necrosis in the brain. Genetic risk loci for NME previously were identified in pug dogs, particularly associated with the dog leukocyte antigen (DLA) class II complex on chromosome 12, but have not been investigated in other susceptible breeds. We sought to evaluate Maltese and Chihuahua dogs,...
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