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Article

A GJA9 frameshift variant is associated with polyneuropathy in Leonberger dogs.

BMC genomics - 25 Aug 2017

Becker Doreen, Minor Katie M, Letko Anna, Ekenstedt Kari J, Jagannathan Vidhya, Leeb Tosso, Shelton G Diane, Mickelson James R, Drögemüller Cord

Abstract excerpt

BACKGROUND: Many inherited polyneuropathies (PN) observed in dogs have clinical similarities to the genetically heterogeneous group of Charcot-Marie-Tooth (CMT) peripheral neuropathies in humans. The canine disorders collectively show a variable expression of progressive clinical signs and ages of onset, and different breed prevalences. Previously in the Leonberger breed, a variant highly associated with a...

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Source

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Identifiers

PMID: 28841859
DOI: 10.1186/s12864-017-4081-z
PMCID: PMC5574090

Genes

GJA9
ARHGEF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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