Article
Degenerative myelopathy in the Collie breed: a retrospective immunohistochemical analysis of superoxide dismutase 1 in an affected Rough Collie, and a molecular epidemiological survey of the SOD1: c.118G>A mutation in Japan.
The Journal of veterinary medical science - 28 Feb 2017
Kohyama Moeko, Kitagawa Masato, Kamishina Hiroaki, Kobatake Yui, Yabuki Akira, Sawa Mariko, Kakita Shusaku, Yamato Osamu
Abstract excerpt
Canine degenerative myelopathy (DM) is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds. A DM-associated mutation of the canine superoxide dismutase 1 (SOD1) gene, designated as c.118G>A (p.E40K), has been implicated as one of pathogenetic determinants of the disease in many breeds, but it remains to be determined whether the c.118G>A mutation is responsible for development...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.