Article
Genotyping assays for the canine degenerative myelopathy-associated c.118G>A (p.E40K) mutation of the SOD1 gene using conventional and real-time PCR methods: a high prevalence in the Pembroke Welsh Corgi breed in Japan.
The Journal of veterinary medical science - 1 Jan 2013
Chang Hye-Sook, Kamishina Hiroaki, Mizukami Keijiro, Momoi Yasuyuki, Katayama Masaaki, Rahman Mohammad Mahbubur, Uddin Mohammad Mejbah, Yabuki Akira, Kohyama Moeko, Yamato Osamu
Abstract excerpt
Canine degenerative myelopathy is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds, particularly Pembroke Welsh Corgis. Recently, a degenerative myelopathy-associated mutation of the canine SOD1 gene was identified as c.118G>A (p.E40K). In the present study, genotyping assays using conventional and real-time PCR methods were developed, and a preliminary genotyping survey...
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