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Genome-wide association analysis reveals a <i>SOD1</i> mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

2 Feb 2009

Abstract excerpt

Canine degenerative myelopathy (DM) is a fatal neurodegenerative disease prevalent in several dog breeds. Typically, the initial progressive upper motor neuron spastic and general proprioceptive ataxia in the pelvic limbs occurs at 8 years of age or older. If euthanasia is delayed, the clinical signs will ascend, causing flaccid tetraparesis and other lower motor neuron signs. DNA samples from 38 DM-affected...

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PMID: 19188595
DOI: 10.1073/pnas.0812297106

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