Article
Degenerative Myelopathy in Hovawart Dogs: Molecular Characterization, Pathological Features and Accumulation of Mutant Superoxide Dismutase 1 Protein.
Journal of comparative pathology - 1 Jan 2021
Mandrioli Luciana, Gandini Gualtiero, Gentilini Fabio, Chiocchetti Roberto, Turba Maria E, Avallone Giancarlo, Pellegrino Valeria, Menchetti Marika, Kobatake Yui, Kamishina Hiroaki, Cantile Carlo
Abstract excerpt
Degenerative myelopathy (DM) is an adult-onset, progressive neurological disease affecting several breeds of dog. Homozygosity or compound heterozygosity for the canine superoxide dismutase 1 (SOD1) gene mutations, possibly modulated by the modifier SP110 locus, are associated with a high risk for DM. Although the pathophysiological mechanisms are largely unknown, a role for mutant SOD1 in causing neuronal...
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