Back to search

Article

A meta-analysis of the endothelial protein C receptor rs867186 genotype in malaria

2019-10-18

Abstract excerpt

BACKGROUND : During P. falciparum infection, the binding of P. falciparum erythrocyte membrane protein 1 (PfEMP1) to endothelial cells (EC) results in the sequestration of pRBC. Several receptors located on the endothelial cells, including intercellular adhesion molecule 1 (ICAM-1), CD36, and endothelial protein C receptor (EPCR), contribute to PfEMP1 adhesion to the microvasculature. PfEMP1, expressed on the surf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9a0e2323-1a37-5dfe-91cf-405e16d45d3f
DOI
10.21203/rs.2.9986/v3
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A meta-analysis of the endothelial protein C receptor rs867186 genotype in malariaDOI 10.21203/rs.2.9986/v3
The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.Semantic proximity
Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites.Semantic proximity
Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.Semantic proximity
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomassSemantic proximity
Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria.Semantic proximity
Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania.Semantic proximity
A functional single-nucleotide polymorphism in the CR1 promoter region contributes to protection against cerebral malaria.Semantic proximity
Common virulence gene expression in adult first-time infected malaria patients and severe casesSemantic proximity
Influence of common variants of TLR4 and TLR9 on clinical outcomes of Plasmodium falciparum malaria in Odisha, India.Semantic proximity
Genetic polymorphisms linked to susceptibility to malaria.Semantic proximity
Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.Semantic proximity
Select a neighboring publication to make it the new centre.