Article

Broadly inhibitory antibodies against severe malaria virulence proteins

2024-01-25

Abstract excerpt

Plasmodium falciparum pathology is driven by the accumulation of parasite-infected erythrocytes in microvessels. This process is mediated by the parasite’s polymorphic erythrocyte membrane protein 1 (PfEMP1) adhesion proteins. A subset of PfEMP1 variants that bind human endothelial protein C receptor (EPCR) through their CIDRα1 domains is responsible for severe malaria pathogenesis. A longstanding question is whet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75e70ca0-6108-55d9-9d5d-e750351a8342
DOI: 10.1101/2024.01.25.577124

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Broadly inhibitory antibodies against severe malaria virulence proteinsDOI 10.1101/2024.01.25.577124Read

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.Semantic proximity Read

Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies.Semantic proximity Read

Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variantsSemantic proximity Read

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protectionSemantic proximity Read

Broadly inhibitory antibodies to severe malaria virulence proteinsSemantic proximity Read

Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1Semantic proximity Read

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read

Multi-protein chimeric antigens, a novel combined approach for efficiently targeting and blocking the blood stage of <i>Plasmodium falciparum</i>Semantic proximity Read

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomassSemantic proximity Read

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity Read

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 VariantsSemantic proximity Read

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity Read