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Article

The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site.

Cell reports - 24 May 2016

Lim Mandy Yu Theng, Ng Alvin Wei Tian, Chou Yuting, Lim Teck Por, Simcox Amanda, Tucker-Kellogg Greg, Okamura Katsutomo

Abstract excerpt

In Drosophila, Dicer-1 binds Loquacious-PB (Loqs-PB) as its major co-factor. Previous analyses indicated that loqs mutants only partially impede miRNA processing, but the activity of minor isoforms or maternally deposited Loqs was not eliminated in these studies. We addressed this by generating a cell line from loqs-null embryos and found that only ∼40% of miRNAs showed clear Loqs dependence. Genome-wide...

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Identifiers

PMID: 27184838
DOI: 10.1016/j.celrep.2016.04.059
PMCID: PMC4880499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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