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Article

Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance.

Genes & development - 1 Apr 2026

Shang Renfu, Popitsch Niko, Lee Seungjae, Ameres Stefan L, Lai Eric C

Abstract excerpt

While most conserved microRNA (miRNA) transcripts harbor a suite of features that mediate their efficient biogenesis into small RNAs, some loci bear suboptimal attributes that enable additional layers of processing regulation. A notable example is cluster assistance, whereby a miRNA hairpin with suboptimal nuclear biogenesis can be enhanced by an optimal neighbor. This process involves local transfer of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41571464
DOI: 10.1101/gad.353316.125
PMCID: PMC13041549

Genes

ERH
DGCR8
SAFB
SAFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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