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Article

Functional parameters of Dicer-independent microRNA biogenesis.

RNA (New York, N.Y.) - 1 May 2012

Yang Jr-Shiuan, Maurin Thomas, Lai Eric C

Abstract excerpt

Until recently, a Dicer-class RNase III enzyme was believed to be essential for microRNA (miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this expectation and instead matures by direct cleavage of its pre-miRNA hairpin via the Slicer activity of Argonaute2 (Ago2). In this study, we used structure-function analysis to define the functional parameters of Ago2-mediated miRNA...

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Share to Argonaute Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22461413
DOI: 10.1261/rna.032938.112
PMCID: PMC3334703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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