Article
Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila.
RNA (New York, N.Y.) - 1 Aug 2014
Mohammed Jaaved, Bortolamiol-Becet Diane, Flynt Alex S, Gronau Ilan, Siepel Adam, Lai Eric C
Abstract excerpt
The propensity of animal miRNAs to regulate targets bearing modest complementarity, most notably via pairing with miRNA positions ∼2-8 (the "seed"), is believed to drive major aspects of miRNA evolution. First, minimal targeting requirements have allowed most conserved miRNAs to acquire large target cohorts, thus imposing strong selection on miRNAs to maintain their seed sequences. Second, the modest pairing...
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